Free Thyroxine T4
Abnormally low free t 4 levels may signal hypothyroidism.
Free thyroxine t4. Free thyroxine free t4 tests are used to help evaluate thyroid function and diagnose thyroid diseases including hyperthyroidism and hypothyroidism usually after discovering that the thyroid stimulating hormone tsh level is abnormal. A free thyroxine test often called a free t4 test measures the amount of free thyroxine in your blood. Some of your t4 exists as. Your thyroid produces a hormone called thyroxine which is known as t4.
As your free t4 level rises because it cant convert to free t3 it shows up as high levels of free t4 in the serum. The t4 test can also detect problems with your pituitary gland. A level of free t 4 that is higher than normal could mean you have an overactive thyroid. When t4 is created some of the hormone gets bound to proteins while the rest circulates freely.
This means your thyroid is not making enough hormones. This gland releases tsh thyroid stimulating hormone that directs the thyroid to release its hormones. So your lab tests may look something like this. These high levels of free t4 actually act to suppress your tsh because your pituitary doesnt have the same deiodinases as the rest of the body 4.
Other tests measure just free t4. Talk to your doctor about the meaning of your specific test results. 1 the includes t4 that has bonded with protein interfering with its ability to enter certain tissue and t4 that has not bonded to protein. This hormone plays a role in several of your bodys functions including growth and metabolism.
A free t4 measures what is not bound and able to enter and affect the body tissues. Total t4 is the total amount of thyroxine circulating in the blood. A free t4 test measures only thyroxine thats not bound to proteins. The normal range for free t 4 in adults is 08 to 28 nanograms per deciliter ngdl.
Blood tests can measure total t4 free t4 total t3 or free t3. Conditions associated with hyperthyroidism include graves disease an autoimmune disorder. Most of the t4 and t3 circulate in the blood bound to protein while a small percentage is free unbound. A free t4 test is considered more accurate than a total t4 test for checking thyroid function.
T4 is the main form of thyroid hormone circulating in the blood. Free thyroxine free t4 total t4 concentration thyroxine screen free t4 concentration. Normal results for t4 test a typical normal range is 45 to 112 micrograms per deciliter mcgdl. Many doctors today use the free t4 test because its more accurate than the test for bound t4.
Free t4 is the type not bonded to protein and is considered the active form of thyroxine. A total t4 measures the bound and free hormone and can change when binding proteins differ see above.
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